A dual-CPU computer-based multimedia system is provided, including a computer connected to a multimedia playing control module. The multimedia playing control module has a second CPU connected to the computer through a bus, a multimedia activation and playing system memory connected to the second CPU and storing a second operating system and a kernel program, and at least a hotkey, connected to the second CPU through a hotkey interface circuit, with each hotkey corresponding to a multimedia player. When the second PCU detects any hotkey being operated, the second PCU loads the kernel of the second operating system from the multimedia activation and playing system memory and executes the kernel. Then, the second CPU loads and executes the driver and the application program for the multimedia player corresponding to the operated hotkey.