Embodiments of the present invention generally provide methods and systems for managing gas cylinders by using radio-frequency identification (RFID) technology. In one embodiment, each gas cylinder includes a RFID transponder configured to transmit a RFID signal. The RFID signal may include an identifier for the gas cylinder, as well as data such as gas pressure, temperature, flow rate, battery level, etc. The RFID signals are received by RFID receivers, and are transmitted to a server (e.g., via a computer network). In one embodiment, the gas cylinder data received by the server is collected in a database, and thereafter used by a gas cylinder management software application. The gas cylinder management application performs tasks including selectively generating alarms, locating specific gas cylinders, and replenishment of gas supplies.