The invention provides a method for diagnosing a disorder or disease
associated with an imbalance of monoamines in a subject, or of diagnosing
susceptibility of the subject to the same, wherein the method comprising
(a) providing a sample from a subject to be tested, (b) measuring the
levels of dopamine, melatonin and/or serotonin in the sample; and (c)
comparing the levels measured in step (b) with levels of dopamine,
melatonin and/or serotonin associated with a reference population of
subjects, wherein a difference in one or more of the levels measured in
step (b) with the levels of dopamine, melatonin and serotonin associated
with the reference population of subjects is indicative of a positive
diagnosis. The invention further provides a method of prevention or
treatment of a disorder or disease associated with an imbalance of
monoamines, and kits for the same.