The present invention relates to a method for treating or preventing
fibrosis and improving kidney function comprising administering a Hovenia
dulcis Thunb extract and/or a Lindera obtusiloba extract to the subject.
The method of the present invention can lower the level of GOT, GPT, ALP,
BUN and total bilirubin; improve kidney functions; lower the amount of
hydroxyproline in liver but increase the amount of hydroxyproline in
kidney, suggesting that the extract above has excellent anti-fibrosis and
kidney protecting effects; lower the level of malondialdehyde, suggesting
that the extract has excellent anti-oxidative effect; and promote cell
viability in liver and kidney cell lines, indicating that the extract has
excellent liver and kidney cell protective effects.