The object of the present invention is to provide a preventive and relieving medicine for activated matrix metalloproteinase-causing disorders and diseases, which contains a solvent extract of Ganoderma mushroom.The preventive and relieving medicine for activated matrix metalloproteinase (MMP)-causing disorders and diseases according to the present invention contains the solvent extract of Ganoderma mushroom. The solvent extract of Ganoderma mushroom has MMP inhibiting behaviors and is effective for prevention, suppression, and symptomatic relief of various activated MMP-causing disorders and diseases, such as metastasis of cancers, ulceration, rheumatoid arthritis, osteoporosis, periodontitis, and aging of skin.