An apparatus and method for detecting a space-time multi-user signal are disclosed. The apparatus includes: an RF/IF processing unit for converting received signals through an array antenna into digital baseband signals; a splitting unit for dividing the digital baseband signals into data signals and reference signals; a estimating unit for estimating a delay time information and a channel impulse response; a vector generating unit for receiving the reference signals and the delay time information of to thereby generate a beamforming weight vector; a matrix generating unit for receiving the channel impulse response and the beamforming weight vector to there by generate a system matrix; a filtering unit for receiving the data signals and the system matrix to multiply the system matrix to data per each antenna; a antenna combining unit for combining signals outputted from the filtering unit; and an interference cancelling unit for cancelling an interference signal.