Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (II): ##STR00001## where x, y, A, D, E, T, Q, G, Z, J, K, L, M, W, V, R.sup.2, R.sup.3, R.sup.5, R.sup.5a, R.sup.6, R.sup.6a, R.sup.7, R.sup.7a, R.sup.8 and R.sup.8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (II) are also disclosed.