Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from -550 to -487 in the promoter of the human TNF-.alpha. gene. Additionally, the level of the mRNA transcript encoding the isolated polypeptide is substantially increased in response to LPS stimulation in cultured THP-1 cells.

 
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< Card domain containing polypeptides, encoding nucleic acids, and methods of use

> Nucleic acid molecules which encode antibodies that bind CD40

> Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
~ 00563