An apparatus (20) for making nanopowder includes a reaction chamber (22), a first sprayer (25, 27), a second sprayer (26, 28) and a centrifuge (24). The reaction chamber includes a top portion (224); a bottom portion (227) opposite to the top portion; a peripheral sidewall (220, 223) interconnecting the top portion and the bottom portion; an inlet (222) formed in the top portion configured for introducing a solvent; and an outlet (229) formed in the bottom portion. The first sprayer is formed on the peripheral sidewall of the reaction chamber configured for spraying a first reactant into the reaction chamber. The second sprayer is formed in at least one of the top and bottom portions of the reaction chamber configured for spraying a second reactant into the reaction chamber. The centrifuge is connected with the outlet of the reaction chamber.