The present invention relates generally to phenylglycinamide derivatives
that inhibit serine proteases. In particular it0 is directed to novel
phenylglycinamide derivatives, and analogues thereof, which are useful as
selective inhibitors of serine protease enzymes of the coagulation
cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor
IXa, and/or plasma kallikrein. In particular, it relates to compounds
that are factor VIIa inhibitors. This invention also relates to
pharmaceutical compositions comprising these compounds and methods of
using the same.