The present invention provides conjugates between Factor VII or Factor
VIIa peptides and PEG moieties. The conjugates are linked via an intact
glycosyl linking group that is interposed between and covalently attached
to the peptide and the modifying group. The conjugates are formed from
both glycosylated and unglycosylated peptides by the action of a
glycosyltransferase. The glycosyltransferase ligates a modified sugar
moiety onto either an amino acid or glycosyl residue on the peptide. Also
provided are pharmaceutical formulations including the conjugates.
Methods for preparing the conjugates are also within the scope of the
invention.