An isolated surface protein known as mp58 is provided from the yeast
Candida albicans which has specific active peptide and carbohydrate
regions and immunogenic epitopes therein and which elicits strong
antibody responses during candidiasis. Antibodies raised from mp58 and
the immunogenic regions and epitopes therein are also provided which can
recognize the protein and its active regions and epitopes. The protein
and antibodies of the present invention will thus be useful in methods of
diagnosing, monitoring, treating or preventing infection of C. albicans
and other yeast, and can also provide the basis for the development of
immunity-based prophylactic, therapeutic and diagnostic techniques for
the identification and management of disease conditions such as
candidiasis.