A system and method for segmentation of structures in an image based on curvature slope are provided, the system including a processor, a curvature slope unit in signal communication with the processor for computing curvature slopes in the image and discarding voxels having a slope not satisfying specifications, and a segmentation unit in signal communication with the processor for locating connected clusters of retained voxels; and the method including computing curvature slopes in the image, discarding voxels having a slope not satisfying specifications, and locating connected clusters of retained voxels.