Provided are systems using compression devices for a mammography unit, and methods of using the same. The instant mammography units can comprise at least one x-ray transparent inflatable chamber. When fluid is introduced into the chamber, at least one surface of the chamber expands, and the breast and its vasculature are compressed. Fluid may also be released from the chamber, and as the chamber deflates, blood flow to the breast is restored, producing Korotkoff sounds. Sound data may be obtained with respect to both of a patient's breasts, and the sound data from a patient's first breast may be compared with the data obtained from the contralateral breast. The detected sounds, the comparison data, or both may assist a radiologist in identifying regions of interest on a mammogram, and to enhance a computer-assisted detection (CAD) process and a database of mammography images.