A targeting fusion protein comprising a component that comprises a (i)
ligand or derivative or fragment thereof that binds a pre-selected target
surface protein, such as a receptor, and (ii) an active agent or
therapeutic agent(s), and further optionally (iii) a multimerizing
component and/or (iv) a signal sequence. In a preferred embodiment, the
targeting fusion polypeptide targets muscle and is useful to treat a
muscle-related disease or condition, such as muscle atrophy.