The invention herein describes an improved and novel means of managing the complications of opioid analgesics, specifically treating the induction of emesis and itch by suppressing the activation of sensory afferent nerves. The composition of the botanical components that provides these benefits do not sacrifice hyperalgesia in order to negate the activity of sensory afferent nerves that drive emesis and itch, but in contrast affords significant analgesic actions in its own right. The combination of a therapeutic approach that negates an increased sensitivity to pain, itch, and nausea is a significant improvement over current treatment options.