Disclosed are devices and methods for correlating or aligning pre-surgical image(s) with image(s) observed during a surgical procedure to aid in orientation of tissues and devices for performing a surgical procedure. In a preferred embodiment, the invention provides devices and methods for aligning pre-surgical image(s) of optical tissues or structures, e.g., the retina, with real-time images observed or obtained with a slit lamp, or other optical viewing device. The ability of the subject invention to correlate these images can advantageously provide the physician with greater accuracy when administering surgical treatment, such as with a laser, and can significantly reduce surgery time.