The present invention provides methods of improving the incorporation of
an implantable device into a bone of a host in need thereof. More
particularly, the methods of the present invention include implanting the
device into the bone of a host, wherein the device is at least partially
made of a non-metallic material. Disposed on at least one surface of the
device is an amount of hydroxyapatite and bisphosphonate, which in
combination, are effective to reduce osteolysis and improve incorporation
of the implant into the host bone compared to an implant without the
hydroxyapatite and/or bisphosphonate. The present invention also provides
methods for making such implants, as well as, the implants themselves.