Systems and methods for program directed memory access patterns including a memory system with a memory, a memory controller and a virtual memory management system. The memory includes a plurality of memory devices organized into one or more physical groups accessible via associated busses for transferring data and control information. The memory controller receives and responds to memory access requests that contain application access information to control access pattern and data organization within the memory. Responding to memory access request includes accessing one or more memory devices. The virtual memory management system includes: a plurality of page table entries for mapping virtual memory addresses to real addresses in the memory; a hint state responsive to application access information for indicating how real memory for associated pages is to be physically organized within the memory; and a means for conveying the hint state to the memory controller.