The invention relates to prodrugs of JNK inhibitors and corresponding
methods, formulations, and compositions for inhibiting JNK and treating
JNK-mediated disorders. The application discloses prodrugs of JNK
inhibitors, as described below in formula I:
##STR00001##
wherein m, n, p, q, Q, r, R.sup.1, R.sup.2, R.sup.3, X, X.sup.1, X.sup.2,
X.sup.3, X.sup.4, X.sup.5, Y.sup.1, Y.sup.2, Z.sup.1 and Z.sup.2 areas
defined herein. The compounds and compositions disclosed herein are
useful to modulate the activity of JNK and treat diseases associated with
JNK activity. Disclosed are methods and formulations for inhibiting JNK
and treating JNK-mediated disorders, and the like, with the compounds,
and processes for making said compounds, and corresponding compositions,
disclosed herein.