The invention provides a non-human transgenic animal as a model of type 2
diabetes manifesting a symptom of type 2 diabetes by excessive expression
of the active SREBP-2 protein in pancreatic .beta.-cells by introducing a
recombinant DNA in which a DNA encoding the active SREBP-2 protein is
disposed under the control of a promoter, and a method for screening
therapeutic agents of diabetes using the transgenic animal.