Disclosed are compounds of the formula ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, wherein: M is CH or N; U and W are each CH, or one of U and W is CH and the other is N; X is a bond, alkylene, --C(O)--, --C(N--OR.sup.5)--, --C(N--OR.sup.5)--CH(R.sup.6)--, --CH(R.sup.6)--C(N--OR.sup.5)--, --O--, --OCH.sub.2--, --CH.sub.2O-- or --S(O).sub.0-2--; Y is --O--, --(CH.sub.2).sub.2--, --C(.dbd.O)--, --C(.dbd.NOR.sup.7)-- or --SO.sub.0-2--; Z is a bond, optionally substituted alkylene or alkylene interrupted by a heteroatom or heterocyclic group; R.sup.1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, or benzimidazolyl or a derivative thereof; R.sup.2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods for treating an allergy-induced airway response, congestion, diabetes, obesity, an obesity-related disorder, metabolic syndrome and a cognition deficit disorder using said compounds, alone or in combination with other agents.