Systems and methods for providing memory modules with multiple hub devices. Exemplary systems include a cascade-interconnect memory system with a memory bus, a memory controller and a memory module. The memory controller is in communication with the memory bus for generating, receiving and responding to memory access requests. The memory module includes a first hub device with three or more ports and a second hub device with three or more ports. A first port on the first hub device is in communication with the memory controller via the memory bus, a second port on the first hub device is in communication with a first set of memory devices, and a third port on the first hub device is cascade connected to a first port on the second hub device. A second port on the second hub device is in communication with a second set of memory devices and a third port on the second hub device supports a cascaded connection to a subsequent hub device in the memory system.