An apparatus and method for applying a beneficial agent to the skin is disclosed in one embodiment of the invention as including first and second chemical reactants, each being compatible with the skin. The first and second chemical reactants react with one another to generate a beneficial agent and enhance the permeability of the skin (e.g., by generating heat). The beneficial agent may then be applied to the skin while the permeability of the skin is enhanced. In selected embodiments, the first chemical reactant includes one or more metals, or alloys thereof, that are compatible (i.e., not harmful) with the skin. Similarly, in selected embodiments, the second chemical reactant may include water. In certain embodiments, the beneficial agent generated by the first and second chemical reactants includes an antioxidant such as hydrogen.