Products, compositions, systems, and methods for modifying a target
structure which mediates or is associated with a biological activity,
including treatment of conditions, disorders, or diseases mediated by or
associated with a target structure, such as a virus, cell, subcellular
structure or extracellular structure. The methods may be performed in
situ in a non-invasive manner by application of an initiation energy to a
subject thus producing an effect on or change to the target structure
directly or via a modulation agent. The methods may further be performed
by application of an initiation energy to a subject in situ to activate a
pharmaceutical agent directly or via an energy modulation agent,
optionally in the presence of one or more plasmonics active agents, thus
producing an effect on or change to the target structure. Kits containing
products or compositions formulated or configured and systems for use in
practicing these methods.