This formulaic composition has synergistic effects on the mental function of humans including reduction of mental fatigue, maintenance and enhancement of concentration and mental vigor. The main components are theanine, at levels in excess of 200 mg/dose, and Gingko Biloba extract. Further additions include small amounts of Vitamins B.sub.1, B.sub.2, B.sub.5, B.sub.6 and C as well as some L-Lysine Monohydrochloride. The composition has shown improvements for individuals diagnosed with attention deficit disorder (ADD) and mild autism. Related methods of use are also disclosed.