A needle having a shaft with a distal end defining a distal opening. The
shaft has a longitudinal axis that extends through the distal opening and
the distal opening has a projected area that is smaller than a
cross-sectional area of a section of the shaft proximal to the distal end
of the shaft. Also provided are methods of directly delivering a
therapeutic agent to a target site using a Huber needle or pencil-point
needle.