This invention is related to compounds of general formula (I) wherein X is
oxygen or sulphur or a NR.sup.7 group; R.sup.1 is C.sub.3-C.sub.8 alkyl,
or C.sub.1-C.sub.8 alkyl substituted by phenoxy or phenyl, both phenoxy
or phenyl being optionally substituted by one or more fluoro, chloro,
trifluoromethyl, C.sub.1-C.sub.6 alkyl, hydroxyl, C.sub.1-C.sub.6 alkoxy;
R.sup.2, R.sup.3 are independently hydrogen, C.sub.1-C.sub.6 alkyl,
halogen, trifluoromethyl, hydroxy or C.sub.1-C.sub.6 alkoxy; R.sup.4 is
hydrogen, C.sub.1-C.sub.8 alkyl; R.sup.5, R.sup.6 are independently
hydrogen, C.sub.1-C.sub.3 alkyl, optionally substituted by hydroxy or
phenyl; R.sup.7 is hydrogen or straight or branched C.sub.1-C.sub.3
alkyl; Het is a five to seven membered, saturated or unsaturated
heteromonocyclic or an eight to ten membered, saturated or unsaturated
heterobicyclic group, containing one or more heteroatoms chosen
independently from nitrogen, oxygen and sulphur, said mono- or bicyclic
groups being optionally substituted by C.sub.1-C.sub.6alkyl, halogen,
hydroxyl or C.sub.1-C.sub.6 alkoxy; and the pharmaceutically acceptable
salts or prodrug thereof, that are active as sodium and/or calcium
channel modulators and/or as selective MAO-B inhibitors and therefore
useful in preventing, alleviating and curing a wide range of pathologies,
including, but not limited to, neurological, psychiatric, cardiovascular,
inflammatory, ophthalmic, urologic, metabolic and gastrointestinal
diseases, where the above mechanisms have been described as playing a
pathological role. ##STR00001##