Systems and methods are provided for accessing three dimensional representation of an anatomical surface and flattening the anatomical surface so as to produce a two dimensional representation of an anatomical surface. The two dimensional surface can be augmented with computed properties such as thickness, curvature, thickness and curvature, or user defined properties. The rendered two dimensional representation of an anatomical surface can be interacted by user so as to deriving quantitative measurements such as diameter, area, volume, and number of voxels.