A method, system, and computer program product for tuning a set of chipset parameters to achieve optimal chipset performance under varying workload characteristics. A set of workload characteristics of a current workload type is determined. An instruction stream is generated using weighted parameters derived from the set of workload characteristics of the current workload type. A set of chipset parameters is generated and integrated within the instruction stream. The instruction stream is loaded to one or more processors and executed to collect and analyze performance data relating to the chipset's performance. The analysis includes comparing the set of performance data of a plurality of different instruction streams having the same set of workload characteristics. Each executed instruction stream is executed with at least one different combination of chipset parameters. A determination is made regarding which combination of chipset parameters provides the best performance data for the current workload.