An article has a surface topography for resisting bioadhesion of organisms and includes a base article having a surface. A composition of the surface includes a polymer. The surface has a topography comprising a pattern defined by a plurality of spaced apart features attached to or projected into the base article. The plurality of features each have at least one microscale dimension and at least one neighboring feature having a substantially different geometry. An average feature spacing between adjacent ones of the features is between 10 .mu.m and 100 .mu.m in at least a portion of the surface. The surface topography can be numerically represented using at least one sinusoidal function. In one embodiment, the surface can comprise a coating layer disposed on the base article.