Disclosed are a pharmaceutical composition for external application, an
adhesive skin patch and others which are improved in a drug release
property, transdermal absorbability and stability of a pharmacologically
active ingredient contained therein and can reduce the aggravation of
irritation to the skin. Specifically disclosed is an adhesive skin patch
comprising a support and an adhesive layer laminated on the support,
wherein the adhesive layer contains a pharmaceutical composition for
external application. The pharmaceutical composition for external
application comprises a pharmacologically active ingredient, an auxiliary
component and a pyrrolidone compound, wherein one of the
pharmacologically active ingredient and the auxiliary component has a
carboxylate group in the molecule and the other has a hydroxy group in
the molecule. Preferably, the adhesive layer further comprises a
hydrogenated oil.