An example of a radio frequency (RF) transmitter system for communication may include a transmit pre-distortion module configured to provide a second transmit calibration signal during a transmit calibration mode based on a first transmit calibration signal and one or more transmit calibration adjustment signals. The one or more transmit calibration adjustment signals may include an offset parameter associated with DC offset and an imbalance parameter associated with at least one of gain and phase imbalances. The system may include a transmit channel frequency converter coupled to the transmit pre-distortion module. The transmit channel frequency converter may be configured to provide a fourth transmit calibration signal during the transmit calibration mode based on a third transmit calibration signal and a transmit reference signal.