The present invention relates to a method of identifying a compound for
inhibiting aggregation of proteins involved in diseases linked to protein
aggregation and/or neurodegenerative diseases, comprising the steps of:
(a) bringing into contact a labeled monomeric protein and a differently
labeled aggregate of said protein in the (1) presence and (2) absence of
a candidate inhibitor of aggregation, (b) determining the amount of
co-localized labels, representing the extent of binding of the monomeric
proteins to the aggregates of said protein; and (c) comparing the result
obtained in the presence and absence of said compound, wherein a decrease
of co-localized labels in the presence of said compound is indicative of
the compound's ability to inhibit aggregation of said protein. Moreover,
the present invention relates to a pharmaceutical composition containing
said inhibitor of aggregation as well as to a kit.