The present invention relates to a microneedle therapy system for skin care, hair loss treatment, obesity treatment, and the like. Provided is a multi-injection microneedle therapy system which implements a new treatment device and method capable of inserting a number of needles to create holes on the human skin and simultaneously inject drugs by using a gun, thereby significantly reducing a procedure time, minimizing pain, and increasing drug absorption efficiency to maximize treatment effectiveness. In addition, the multi injection microneedle therapy system can perform microneedle therapy or mesotherapy treatment according to types of injected drugs and effectively perform the mesotherapy treatment by performing a number of injections for a short procedure time.