The present invention provides pyrazole derivatives represented by the
general formula:
##STR00001##
wherein R.sup.1 represents H, an optionally substituted C.sub.1-6 alkyl
group etc.; one of Q and T represents a group selected from the following
groups:
##STR00002##
, and the other represents --(CH.sub.2).sub.n--Ar wherein Ar represents an
optionally substituted C.sub.6-10 aryl group or an optionally substituted
C.sub.1-9 heteroaryl group; and n represents an integral number from 0 to
2, an optionally substituted C.sub.1-6 alkoxyl group, an optionally
substituted amino group, an optionally substituted C.sub.2-9
heterocycloalkyl group or an optionally substituted heterocycle-fused
phenyl group; R represents an optionally substituted C.sub.3-8 cycloalkyl
group, an optionally substituted C.sub.6-10 aryl group etc.,
pharmaceutically acceptable salts thereof or prodrugs thereof, which
exhibit an excellent inhibitory activity in human
1,5-anhydroglucitol/fructose/mannose transporter and are useful as agents
for the prevention, inhibition of progression or treatment of a disease
associated with the excess uptake of at least a kind of carbohydrates
selected from glucose, fructose and mannose or a disease associated with
hyperglycemia (e.g., diabetic complications, diabetes, etc.), and
pharmaceutical compositions comprising the same, pharmaceutical uses
thereof, and intermediates for production thereof.