A composition for accelerating fracture healing, which has a PDE4 inhibitor as an active ingredient, specifically a composition having a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suitable for local administration such as a microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in the early healing of bone fracture. The composition is useful in healing of refractory fracture of elderly people and diabetic or osteoporosis patients.