Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI)
or TFPI variants comprise a solubilizing agent, an antioxidant, and a
buffer. The combination of a solubilizing agent and an antioxidant can
lead to a significant improvement in the storage life of TFPI or TFPI
variant compositions. The solubilizing agent and antioxidant
substantially counteract the effects of TFPI or TFPI variant degradation
through aggregation and oxidation.