A prepress workflow process suitable for generating a reproduction composite image from a source image that may be tolerant to or exhibit improved tolerance to misregistration when printed is provided. Embodiments of the prepress workflow process include obtaining a source image. Next, N.gtoreq.2 color separations are generated from the source image. The color separations may be process or non-process color separations. The N color separations are first processed globally for improving the misregistration tolerance of a reproduction composite image to be formed therefrom. If the misregistration tolerance of the reproduction composite image is not acceptable to be user, at least a portion of each N color separation may be further processed at a local level for producing an improved misregistration tolerant reproduction composite image.