The present invention relates to a first group of novel oligonucleotides,
here identified as Genomic Address Messenger or GAM oligonucleotide, and
a second group of novel operon-like polynucleotides, here identified as
Genomic Record or GR polynucleotide. GAM oligonucleotides selectively
inhibit translation of known `target` genes, many of which are known to
be involved in various diseases. Nucleic acid molecules are provided
respectively encoding 15454 GAM precursors oligonucleotides, and 681 GR
polynucleotides, as are vectors and probes both comprising the nucleic
acid molecules, and methods and systems for detecting GAM
oligonucleotides and GR polynucleotides and specific functions and
utilities thereof, for detecting expression of GAM oligonucleotides and
GR polynucleotides, and for selectively enhancing and selectively
inhibiting translation of the respective target genes thereof.