A system and method for automating the generation and execution of sequences of manual operations, using a structured process and grammar, suitable for implementation in systems integration. The method of the invention allows manual operations to be defined by local or remote subject matter experts (SMEs), using a Manual Operations Grammar, with the system allowing the definition of methods for validating measurements, reporting, and optimizing a set of one or more operations and/or processes. As part of the system, generated scripts can automate a plurality of manual tasks, operation and/or process steps, and a plurality of automated tasks, operation and/or process steps.