The invention relates to bacteria that have increased levels of protein
secretion due to genetic modification, to nucleotide sequences and gene
structures containing at least one gene coding for a SecA protein having
increased levels of protein secretion, to a SecA having increased levels
of protein secretion, and to a method for producing desired proteins
using the inventive bacteria. The invention also relates to nucleic acids
coding for a SecA protein having increased levels of protein secretion,
containing a SecA gene sequence or allele, a SecA homologue or
derivative, or nucleotide sequences hybridising therewith and comprising
at least one mutation. Surprisingly, just one mutation in a nucleotide of
a SecA gene leads to increased levels of protein secretion or to protein
secretion for the first time.