A current-mode differential transmitter, receiving a single-end input voltage signal and accordingly generating a differential output current signal, is provided. The transmitter includes a first switch, a second switch and a current mirror. The first switch is coupled in a first current path and controlled by the single-end input voltage signal. The second switch is coupled in a second current path and controlled by an inverted signal of the single-end input voltage signal. The current mirror mirrors a reference current to the first current path when the first switch is turned on, and mirrors the reference current to the second current path when the second switch is turned on. The differential output current signal is derived from the currents on the first and second current paths.