The present invention discloses pteridinone derivatives for use as
inhibitors of stearoyl-CoA desaturase having the structure of Formula I:
##STR00001## The compounds are useful in treating and/or preventing
various human diseases, mediated by stearoyl-CoA desaturase (SCD)
enzymes, especially diseases related to abnormal lipid levels,
cardiovascular disease, diabetes, obesity, metabolic syndrome and the
like.