A device suitable for removing material from a living being is provided,
featuring an infusate pump, and an aspiration pump, both powered by a
motor. The aspiration pump and infusate pump preferably feature a helical
pumping mechanism, and operate at a high rate of rotation, thereby
ensuring adequate pumping performance and flexibility. Additionally, a
narrow crossing profile is maintained, ensuring that the device may reach
more tortuous regions of the vasculature. In one embodiment, the system
comprises a wire-guided mono-rail catheter with a working head mounted on
a flexible portion of the catheter that can laterally displace away from
the guide wire to facilitate thrombus removal. The working head may be
operated to separate and move away from the guide wire to come within a
closer proximity of the obstructive material to more effectively remove
it from the vessel.