A patient-specific optimally effective radiation dose for administration
of a radiopharmaceutical to a patient for treatment of a disease may be
established by basing the calculation of the appropriate therapeutic dose
on factors such as the desired total body dose, the maximum tolerated
dose, the typical clearance profile of the radiopharmaceutical, the
patient's mass or maximum effective mass, and the patient-specific
residence time of the radiopharmaceutical or an analog in the whole body
of the patient. The use of the method allows for treatment of a patient
with an appropriate dose which is maximally effective against the disease
yet minimally toxic. The determination of a patient-specific therapeutic
dose may be assisted by the use of a software program set to the
particular parameters of the radiopharmaceutical.