Methods and systems using one or more expert systems to screen equipment operators for impairments, such as chemical impairment, physical impairment, medical impairment, or emotional impairment, to selectively test the equipment operators and rescue the equipment operator and control the equipment (e.g., automobiles, trucks, industrial vehicles, public transportation vehicles, such as buses, subways, trains, planes, ships, watercraft, sport vehicles, and dangerous or potentially dangerous machinery in general) if impairment of the equipment operator is determined. One embodiment is a method to screen and rescue an equipment operator having a chemical impairment, using one or more expert systems. A second embodiment is a method to screen and rescue an equipment operator having an impairment, such as chemical impairment, physical impairment, medical impairment, or emotional impairment, using one or more expert systems. A third embodiment is an equipment operator screening system to determine impairment, such as chemical impairment, physical impairment, medical impairment, or emotional impairment, using one or more expert systems, and rescue the equipment operator and control the equipment.