Systems and methods for non-thermal ablation of tissue are provided. A non-implantable minimally invasive system for treatment of tissue in a body via direct current ablation is provided. A catheter for use in such system is further provided. The catheter includes a tubular body having a proximal end, a distal end, and a tip positioned at the distal end. The tubular body is semi-flexible, bi-directionally torqueable, and chemically resistant. The tubular body includes a plurality of routing holes provided between the proximal end and the distal end for facilitating deployment of electrodes from the tubular body. The tubular body further comprises an inner sheath generally at an interior portion and an outer sheath generally at an exterior portion and being chemically resistant.