The present invention relates to noninvasive transdermal systems comprised
of a noninvasive transdermal patch and a reflectometer. The noninvasive
transdermal patches are comprised of a wet chemistry component and a dry
chemistry component. The wet chemistry component is a liquid transfer
medium in the form of a gel layer for the extraction and liquid bridge
transfer of the analyte of interest from the biological fluid within or
beneath the skin to the dry chemistry component. The dry chemistry
component is a reagent system for interacting with the analyte of
interest (glucose) to generate a color change. The reflectometers include
a modulated light source for emitting light to illuminate a target
surface which possesses a certain color and shade of color for detection
by an optical detector. The output signal is processed for determining a
corresponding quantity of quality measurement.