The methods and compositions relate to treatment of disorders of the
bladder. In particular, the methods provide for treatment of interstitial
cystitis and related disorders. The methods further comprise treatment to
affect various manifestations associated with interstitial cystitis,
including, reducing histamine release, modulating Substance P expression,
modulating nerve growth factor expression, modulating levels of various
cytokines, and maintaining integrity of the urine/blood barrier.